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CCT007093 176957-55-4

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Synonyms ：
Appearance ：
Chemical Formula ：
C15H12OS2
Solubility ：
Molecular Weight ：
272.39
Storage and Stability ：
in stock
CAS No. ：
176957-55-4
Purity ：
98%+
Introduction
CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.


CCT007093 selectively and potently inhibits human tumor cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress PPM1D. CCT007093 induces cell death via the activation of p38 kinase activity. [1] CCT007093 in combination with paclitaxel, results in synergistic inhibition of the four paclitaxel-resistant triple-negative breast cancer (TNBC) cell lines. [2] CCT007093 selectively promote apoptosis in breast cancer cells and skin transformed keratinocytes that ectopically expressed Wip1, while attenuates the UV-mediated apoptotic response in both skin keratinocytes and a Wip1-null cell model. [3]

 
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