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CB-839 1439399-58-2

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Synonyms ：
Appearance ：
Chemical Formula ：
C26H24F3N7O3S
Solubility ：
Molecular Weight ：
571.57
Storage and Stability ：
in stock
CAS No. ：
1439399-58-2
Purity ：
98%+
Introduction
CB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. Phase 1.


CB-839 exhibits time-dependent and slowly reversible kinetics. IC50 values for glutaminase inhibition by CB-839 following preincubation with rHu-GAC for-1 hour are < 50 nmol/L, at least 13-fold lower than with BPTES. CB-839 has antiproliferative activity in a triple-negative breast cancer (TNBC) cell line, HCC-1806, while no antiproliferative activity is observed in an estrogen receptor–positive cell line, T47D.[1]

 
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