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BAY 87-2243 1227158-85-1

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Synonyms ：
Appearance ：
Chemical Formula ：
C26H26F3N7O2
Solubility ：
Molecular Weight ：
525.53
Storage and Stability ：
in stock
CAS No. ：
1227158-85-1
Purity ：
98%+
Introduction
BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. Phase 1.

 
BAY 87-2243 inhibits HIF-1 reporter gene activity and CA9 protein expression with IC50 of 0.7 nM and 2 nM, respectively. In hypoxic lung cancer H460 cells, BAY 87-2243 suppresses HIF target gene expression, and inhibits HIF-1α protein accumulation. Under glucose depletion, BAY 87-2243 inhibits cell proliferation via interference with mitochondrial function. [1]

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