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BAY 11-7085 196309-76-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C13H15NO2S
Solubility ：
Molecular Weight ：
249.33
Storage and Stability ：
in stock
CAS No. ：
196309-76-9
Purity ：
98%+
Introduction
BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.

BAY 11-7085 inhibits TNFα-induced expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibition of NF-κB without detectable cytotoxicity at 10 μM in HUVEC cells. [1] BAY 11-7085 enhances the inhibition of NFkappaB activity by paclitaxel and decreases the viability of cells treated with paclitaxel. [3] Besides, combination of Bay11-7085 and LY294002 leads to synergistic apoptotic effect in PEL cells. [4]

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