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Baricitinib 1187594-09-7

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Synonyms ：
Appearance ：
Chemical Formula ：
C16H17N7O2S
Solubility ：
Molecular Weight ：
371.42
Storage and Stability ：
in stock
CAS No. ：
1187594-09-7
Purity ：
98%+
Introduction
Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Phase 3.
 
Baricitinib inhibits IL-6–stimulated phosphorylation of the canonical substrate STAT3 (pSTAT3) and subsequent production of the chemokine MCP-1 with IC50 values of 44 nM and 40 nM, respectively, in PBMCs. Baricitinib also inhibits pSTAT3 stimulated by IL-23 with IC50 od 20 nM in isolated naive T-cells. [1]

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