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AZ191 1594092-37-1

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Synonyms ：
Appearance ：
Chemical Formula ：
C24H27N7O
Solubility ：
Molecular Weight ：
429.52
Storage and Stability ：
in stock
CAS No. ：
1594092-37-1
Purity ：
98%+
Introduction
AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

AZ191 selectively inhibits DYRK1B serine/threonine kinase activity with no effect on tyrosine kinase autophosphorylation. In HEK-293 cells, AZ191 also displays much greater potency for DYRK1B over DYRK1A, inhibiting CCND1 phosphorylation. In HD1B cells, AZ191 strongly inhibits the levels of the cell-cycle regulators, p21Cip1 and p27Kip1, and increases cell-cycle progression. [1]

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