Alvelestat 848141-11-7

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Synonyms

：

Appearance

：

Chemical Formula

：

C25H22F3N5O4S

Solubility

：

Molecular Weight

：

545.53

Storage and Stability

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in stock

CAS No.

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848141-11-7

Purity

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98%+

Introduction

Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.

AZD9668 inhibits plasma NE activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells. [1]

Products for scientific research use only

Alvelestat 848141-11-7

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Alvelestat 848141-11-7

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CAS No. ：

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