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AT9283 896466-04-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C19H23N7O2
Solubility ：
Molecular Weight ：
381.43
Storage and Stability ：
in stock
CAS No. ：
896466-04-9
Purity ：
98%+
Introduction
AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl(T315I). Phase 2.

AT9283 leads to a clear polyploid phenotype by inhibiting the activity of Aurora B kinase in HCT116 cells with IC50 of 30 nM. Furthermore, AT9283 also produces the potent inhibition on HCT116 colony formation. [1]

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