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AT13148 1056901-62-2

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Synonyms ：
Appearance ：
Chemical Formula ：
C17H16ClN3O
Solubility ：
Molecular Weight ：
313.78
Storage and Stability ：
in stock
CAS No. ：
1056901-62-2
Purity ：
98%+
Introduction
AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.

AT13148, as a multi-AGC kinase inhibitor, potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines with deregulation of PI3K-AKT-mTOR or RAS-RAF pathways. In PTEN-deficient MES-SA cells, AT13148 also inhibits AKT and p70S6K signaling. [1]

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