Ascomycin 104987-12-4

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Synonyms

：

Appearance

：

Chemical Formula

：

C43H69NO12

Solubility

：

Molecular Weight

：

792.01

Storage and Stability

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in stock

CAS No.

：

104987-12-4

Purity

：

98%+

Introduction

Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.

Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. [1] Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex. FK520 also accelerate the rate of nerve regeneration, and promotes neurite outgrowth. [2] Ascomycin shows antimalarial effects via inhibition of the chaperone activity of this bifunctional protein. [3]

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Ascomycin 104987-12-4

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Ascomycin 104987-12-4

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