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AGI-6780 1432660-47-3

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Synonyms ：
Appearance ：
Chemical Formula ：
C21 H18 F3 N3 O3 S2
Solubility ：
Molecular Weight ：
481.51
Storage and Stability ：
in stock
CAS No. ：
1432660-47-3
Purity ：
98%+
Introduction
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.


AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples. 

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