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A-966492 934162-61-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C18H17FN4O
Solubility ：
Molecular Weight ：
324.35
Storage and Stability ：
in stock
CAS No. ：
934162-61-5
Purity ：
98%+
Introduction
A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.


A-966492 is one of the most potent PARP inhibitors. A-966492 displays excellent potency against the PARP-1 enzyme with a Kiof 1 nM and an EC50 of 1 nM in a whole cell assay. A-966492 significantly enhances the efficacy of TMZ in a dose-dependent manner. In addition, A-966492 is orally bioavailable across multiple species, crosses the blood−brain barrier, and appears to distribute into tumor tissue. A-966492 represents a promising, structurally diverse benzimidazole analogue and is being further characterized preclinically.

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