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A-674563 552325-73-2

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Synonyms ：
Appearance ：
Chemical Formula ：
C22H22N4O
Solubility ：
Molecular Weight ：
358.44
Storage and Stability ：
in stock
CAS No. ：
552325-73-2
Purity ：
98%+
Introduction
A-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >30-fold selective for Akt1 over PKC.
 
A-674563 is achieved from A-443654 by replacing the indole with a phenyl moiety and getting oral activity. A-674563 slows proliferation of tumor cells with EC50 of 0.4 μM. [1] A-674563 does not inhibit Akt phosphorylation per se, but blocks the phosphorylation of Akt downstream targets in a dose-dependent manner. A-674563 induced Akt blockade results in decreased STS cell downstream target phosphorylation and tumor cell growth inhibiton. A-674563 induces G2 cell cycle arrest and apoptosis in STS cells. 

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