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Odanacatib MK0822 603139-19-1

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Synonyms ：
Appearance ：
Chemical Formula ：
C25H27F4N3O3S
Solubility ：
Molecular Weight ：
525.56
Storage and Stability ：
in stock
CAS No. ：
603139-19-1
Purity ：
99%+
Introduction
Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.

In vitro, Odanacatib shows the high inhibitory activity and selectivity on cathepsin K with IC50 values of 0.2 nM and 1 nM for human cathepsin K and rabbit cathepsin K, respectively. Furthermore, Odanacatib also shows similar potencies in whole human cell enzyme occupancy assays with corrected IC50 of 5 nM. A recent study shows that Odanacatib results in reduction of Osteoclast (OC) resorption activity by interrupting intracellular vesicular trafficking. 

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