LY2409881 946518-60-1

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Synonyms

：

Appearance

：

Chemical Formula

：

C24H32Cl4N6OS

Solubility

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Molecular Weight

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594.43

Storage and Stability

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in stock

CAS No.

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946518-60-1

Purity

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98%+

Introduction

LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.

LY2409881 inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth.

LY2409881 946518-60-1

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LY2409881 946518-60-1

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