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LY2090314 603288-22-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C28H25FN6O3
Solubility ：
Molecular Weight ：
512.53
Storage and Stability ：
in stock
CAS No. ：
603288-22-8
Purity ：
98%+
Introduction
LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.

LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro. 

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