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Ribociclib LEE011 1211441-98-3

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Synonyms ：
Appearance ：
Chemical Formula ：
C23H30N8O
Solubility ：
Molecular Weight ：
434.54
Storage and Stability ：
in stock
CAS No. ：
1211441-98-3
Purity ：
98%+
Introduction
Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.

Orally bioavailable CDK4/6-selective inhibitor that has been tested in Phase III clinical trials for treatment of advanced breast cancer.

LEE011, as dual CDK4/CDK6 inhibitor, significantly inhibits the growth of 12 of 17 neuroblastoma cell lines with mean IC50 of 307 nM. The growth inhibition of neuroblastoma cell lines is primarily cytostatic and is mediated by a G1 cell-cycle arrest and cellular senescence.

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