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Irbinitinib ARRY-380 937263-43-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C26H24N8O2
Solubility ：
Molecular Weight ：
480.52
Storage and Stability ：
in stock
CAS No. ：
937263-43-9
Purity ：
99%+
Introduction
ARRY-380 (ONT-380) is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity.

The compound is a reversible, ATP-competitive inhibitor with nanomolar potency against ErbB2 in both in vitro and in cell-based assays[1]. In cell-based assays, ARRY-380 is ~500-fold selective for HER2 vs. EGFR and is equipotent against truncated p95-HER2.

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