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INCB024360 analogue 914471-09-3

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Synonyms ：
Appearance ：
Chemical Formula ：
C9H7ClFN5O2
Solubility ：
Molecular Weight ：
271.64
Storage and Stability ：
in stock
CAS No. ：
914471-09-3
Purity ：
98%+
Introduction
INCB024360 analogue is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM. Phase 2.

In HeLa cells, INCB024360 shows higher inhibitory activity on IDO1 with IC50 of 19 nM.  In coculture systems of human allogeneic lymphocytes with dendritic cells or tumor cells, INCB024360, via IDO1 inhibition, reverses T-cell suppression mediated by IDO-expressing HeLa cells or DCs, and increases the proliferation and functional activity of CD4+ T cells, CD8+ T cells, and NK cells.

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