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HTH-01-015 1613724-42-7

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Synonyms ：
Appearance ：
Chemical Formula ：
C26H28N8O
Solubility ：
Molecular Weight ：
468.55
Storage and Stability ：
in stock
CAS No. ：
1613724-42-7
Purity ：
98%+
Introduction
HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.

In HEK-293 cells express NUAK1 as well as NUAK2, HTH-01-015 suppresses NUAK1-mediated MYPT1 phosphorylation. HTH-01-015 suppresses cell migration In NUAK1+/+ MEFs, and inhibit U2OS cell invasion. Moreover, HTH-01-015 inhibits cell proliferation in both cell lines. HTH-01-015 inhibitors markedly restricted cells from entering into mitosis in U2OS cells.

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