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GSK591 EPZ015866 1616391-87-7

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Synonyms ：
Appearance ：
Chemical Formula ：
C22H28N4O2
Solubility ：
Molecular Weight ：
380.48
Storage and Stability ：
in stock
CAS No. ：
1616391-87-7
Purity ：
98%+
Introduction
GSK591 (EPZ015866,GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM.

In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases.

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