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GDC-0349 1207360-89-1

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Synonyms ：
Appearance ：
Chemical Formula ：
C24H32N6O3
Solubility ：
Molecular Weight ：
452.55
Storage and Stability ：
in stock
CAS No. ：
1207360-89-1
Purity ：
98%+
Introduction
GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.

GDC-0349 has remarkable selectivity over 266 kinases, including all isoforms of PI3K. GDC-0349 inhibits downstream markers of mTOR, including phospho-4EBP1 and phospho-Akt(S473) in an in vivo PK/PD study in mouse, consistent with an inhibition of both mTORC1 and mTORC2 complexes. 

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