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FRAX-1036 1432908-05-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C28H32ClN7O
Solubility ：
Molecular Weight ：
518.05
Storage and Stability ：
in stock
CAS No. ：
1432908-05-8
Purity ：
98%+
Introduction
FRAX-1036 is a potent and selective PAK1 inhibitor.

Potent cellular inhibition of group I PAK substrate phosphorylation (MEK1-S298 and CRAF-S338) was observed at 2.5 to 5 μM concentrations of FRAX1036 in PAK1-amplified MDA-MB-175 cells. Treatment of PAK1-amplified breast cancer cells with FRAX1036 results in apoptosis. And treatment of OVCAR-3 cells with FRAX-1036 results in upregulation of p53 and p21, while down-regulating cyclin B1.

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