Erastin 571203-78-6

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Synonyms

：

Appearance

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Chemical Formula

：

C30H31ClN4O4

Solubility

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Molecular Weight

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547.04

Storage and Stability

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in stock

CAS No.

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571203-78-6

Purity

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98%+

Introduction

Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS.

Erastin is selectively lethal to oncogenic RAS-mutant cell lines, and triggers a unique iron-dependent form of non-apoptotic cell death called ferroptosis. Erastin binds directly to VDAC2 and causes mitochondrial damage via ROS production in an NADH-dependent manner, which induces cell death in some tumor cells harbouring activating mutations in the RAS-RAF-MEK pathway. In addition, erastin, via inducing ROS-mediated CID (Caspase-independent cell death), strongly enhances the effect of cisplatin in WT EGFR cells.

Erastin 571203-78-6

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Erastin 571203-78-6

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