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EPZ015666(GSK3235025) 1616391-65-1

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Synonyms ：
Appearance ：
Chemical Formula ：
C20H25N5O3
Solubility ：
Molecular Weight ：
383.44
Storage and Stability ：
in stock
CAS No. ：
1616391-65-1
Purity ：
98%+
Introduction
EPZ015666(GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.

EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM.

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