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Dabrafenib GSK2118436 1195768-06-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C23H20F3N5O2S2
Solubility ：
Molecular Weight ：
519.56
Storage and Stability ：
in stock
CAS No. ：
1195768-06-9
Purity ：
99%+
Introduction
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.
Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E

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