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GNE-9605 |
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C17H20ClF4N7O |
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DMSO 89 mg/mL (197.85 mM) |
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449.83 |
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10 grams |
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1536200-31-3 |
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98% |
Introduction
GNE-9605 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 19 nM.IC50 value: Target: LRRK2 GNE-9605 retained excellent predicted human metabolic stability when assayed in human liver microsomes and hepatocytes. In addition, no reversible or time-dependent inhibition of any of the major CYP isoforms was observed.