CID755673 521937-07-5

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Synonyms

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Appearance

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Chemical Formula

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C12H11NO3

Solubility

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Molecular Weight

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219.24

Storage and Stability

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in stock

CAS No.

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521937-07-5

Purity

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98%+

Introduction

CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.

In LNCaP prostate cancer cells, CID755673 directly inhibits PKD1 activity. In HeLa cells, CID755673 significantly blocks PMA-induced nuclear export of HDAC5, and blocks PKD-mediated protein transport. In prostate cancer cells, CID755673 potently blocks cell migration and invasion, and also shows inhibition activity on tumor cell proliferation and cell cycle distribution. In addition, CID755673 alter primary human NK cell effector functions.

CID755673 521937-07-5

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CID755673 521937-07-5

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