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CC-223 1228013-30-6

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Synonyms ：
Appearance ：
Chemical Formula ：
C21H27N5O3
Solubility ：
Molecular Weight ：
397.47
Storage and Stability ：
in stock
CAS No. ：
1228013-30-6
Purity ：
98%+
Introduction
CC-223 is a potent, selective, and orally bioavailable mTOR inhibitor with IC50 of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2.

In a panel of cell lines, CC-223 inhibits both mTORC1 (S6RP and 4EBP1) and mTORC2 [AKT(S473)] markers with IC50 ranges of 27 to 184 nM for pS6RP, 120 to 1,050 nM for p4EBP1 and 11 to 150 nM for pAKT(S473), respectively. CC-223 also inhibits cell growth and induces apoptosis across a number of cancer cell lines.


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