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MSDC-0160 146062-49-9

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Synonyms
Appearance
Chemical Formula
C19 H18 N2 O4 S
Solubility
Molecular Weight
370.42
Storage and Stability
in stock
CAS No.
146062-49-9
Purity
98%+
Introduction
MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease. Phase 2.

MSDC-0160 reduces resistance in the insulin/IGF-1 signaling pathway and restores IGF-1-induced Akt and GSK-3 phosphorylation. MSDC-0160 in combination with IGF-1 and 8 mM glucose increases β-cell specific gene expression of insulin, pdx1, nkx6.1, and nkx2.2, and maintains insulin content without altering glucose-stimulated insulin secretion. Furthermore, MSDC-0160 promotes human β-cell differentiation and reduces the expression of markers of apoptosis. 

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