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BMH-21 896705-16-1

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Synonyms ：
Appearance ：
Chemical Formula ：
C21H20N4O2
Solubility ：
Molecular Weight ：
360.41
Storage and Stability ：
in stock
CAS No. ：
896705-16-1
Purity ：
98%+
Introduction
BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.

BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.

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