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BLZ945 953769-46-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C20H22N4O3S
Solubility ：
Molecular Weight ：
398.48
Storage and Stability ：
in stock
CAS No. ：
953769-46-5
Purity ：
98%+
Introduction
BLZ945 is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.

In bone marrow-derived macrophages (BMDMs), BLZ945 specifically inhibits CSF-1-dependent proliferation with EC50 of 67nM, and decreases CSF-1R phosphorylation. BLZ945 blocks the reciprocal effects between macrophages and glioma cells on the survival, proliferation and/ or polarization of each other to promote tumorigenesis.

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