BMH-21

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Synonyms

：

BMH-21

Appearance

：

white powder

Chemical Formula

：

C21H20N4O2

Solubility

：

DMSO 5 mg/mL warmed (13.87 mM)

Molecular Weight

：

360.41

Storage and Stability

：

20grams

CAS No.

：

896705-16-1

Purity

：

98%

Introduction

BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.

BMH-21

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BMH-21

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