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BMH-21

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Synonyms
BMH-21
Appearance
white powder
Chemical Formula
C21H20N4O2
Solubility
DMSO 5 mg/mL warmed (13.87 mM)
Molecular Weight
360.41
Storage and Stability
20grams
CAS No.
896705-16-1
Purity
98%
Introduction
BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.

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