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BAY-876 1799753-84-6

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Synonyms ：
Appearance ：
Chemical Formula ：
C24H16F4N6O2
Solubility ：
Molecular Weight ：
496.42
Storage and Stability ：
in stock
CAS No. ：
1799753-84-6
Purity ：
98%+
Introduction
BAY-876 is a potent and selective GLUT1 inhibitor (IC50=0.002 μM) with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4.

BAY-876 displays low clearance also in vivo in rat and in dog. The volume of distribution in steady state (Vss) is moderate in both species. Terminal half life is intermediate in rat (2.5 h) and long in dog (22 h) due to the very low clearance. The oral bioavailability (F%) is 85% and 79% in rat and dog, respectively. Preliminary in vivo PK studies of BAY-876 demonstrate that a good oral bioavailability and long terminal half-life is attainable making it an excellent chemical probe to further evaluate the hypothesis of cancer treatment with a very selective GLUT1 inhibitor

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