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Lanabecestat AZD3293 1383982-64-6

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Synonyms ：
Appearance ：
Chemical Formula ：
C26H28N4O
Solubility ：
Molecular Weight ：
412.53
Storage and Stability ：
in stock
CAS No. ：
1383982-64-6
Purity ：
98%+
Introduction
Lanabecestat（AZD3293, LY3314814）is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor.

Lanabecestat（AZD3293, LY3314814）is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. When the potency of AZD3293 with respect to secretion of Aβ40 and sAβPPβ is studied in a range of cellular models, the compound displays pM potency in primary neuron cultures from mice and guinea pigs and in SH-SY5Y cells over-expressing AβPP (IC50 = 610 pM, 310 pM, and 80 pM, respectively). AZD3293 is also tested in a panel of more than 350 in vitro radioligand binding and enzyme activity assays, covering a diverse range of receptors, ion channels, transporters, kinases, and enzymes, up to a concentration of 10μM of AZD3293. A few significant responses are observed, but these had at least a 1,000-fold selectivity against BACE1, thus indicating specificity to BACE1.

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