SB 525334

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Synonyms

：

SB-525334

Appearance

：

Chemical Formula

：

C21H21N5

Solubility

：

DMSO 68 mg/mL (198.0 mM)

Molecular Weight

：

343.42

Storage and Stability

：

20grams

CAS No.

：

356559-20-1

Purity

：

98%

Introduction

SB 525334 shows no inhibition in the enzymes ALK2, 3, and 6, with IC50 values > 10 μM. SB 525334 blocks phosphorylation induced by TGF-β1 and nuclear translocation of Smad2/3 in renal proximal tubule cells. SB 525334 also inhibits the increased mRNA expression levels of plasminogen activator inhibitor-1 (PAI-1) and procollagen α1induced by TGF-β1 in A498 renal epithelial carcinoma cells at 1 μM). SB 525334 (1 μM) attenuates the heightened sensitivity to TGF-β1 exhibited by pulmonary artery smooth muscle cells (PASMCs) from patients with familial forms of idiopathic pulmonary arterial hypertension (PAH).

SB 525334

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SB 525334

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