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Almorexant HCl 913358-93-7

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Synonyms ：
Appearance ：
Chemical Formula ：
C29H32ClF3N2O3
Solubility ：
Molecular Weight ：
549.02
Storage and Stability ：
in stock
CAS No. ：
913358-93-7
Purity ：
98%+
Introduction
Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

Orally bioavailable orexin receptor antagonist that has been tested in Phase III clinical trials for treatment of Insomnia.

Almorexant inhibits the increase in intracellular Ca2+ induced by 10 nM human orexin-A in Chinese hamster ovary cells with IC50 of 16 nM (rat) and 13 nM (human) for the OX1 receptor and 15 nM (rat) and 8 nM (human) for the OX2 receptor.

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