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Lesinurad 878672-00-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C17H14BrN3O2S
Solubility ：
Molecular Weight ：
404.28
Storage and Stability ：
in stock
CAS No. ：
878672-00-5
Purity ：
99%+
Introduction
Lesinurad is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout in combination with xanthine oxidase inhibitors.

Lesinurad inhibits the uric acid transport activity of human URAT1 (hURAT1) at a 20-fold higher potency compared to rat URAT1 (rURAT1), with IC50's of 3.36 and 74.84 μM, respectively. Lesinurad inhibits hURAT1 through an interaction that involves a critical residue, Phe365

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