ABT-199;Venetoclax

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Synonyms

：

GDC-0199;

Appearance

：

white powder

Chemical Formula

：

C45H50ClN7O7S

Solubility

：

DMSO 100 mg/mL warmed (115.14 mM)

Molecular Weight

：

868.44

Storage and Stability

：

20grams

CAS No.

：

1257044-40-8

Purity

：

98%

Introduction

ABT-199 is a potent and selective inhibitor of B-cell lymphoma-2 (BCL-2) family proteins, currently in clinical trials. ABT-199 inhibits the growth of BCL-2-dependent tumors in vivo and spares human platelets. A single dose of ABT-199 in three patients with refractory chronic lymphocytic leukemia resulted in tumor lysis within 24 h. These data indicate that selective pharmacological inhibition of BCL-2 shows promise for the treatment of BCL-2-dependent hematological cancers.

ABT-199;Venetoclax

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ABT-199;Venetoclax

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