Selinexor 1393477-72-9

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Synonyms

：

Appearance

：

white powder

Chemical Formula

：

C17H11F6N7O

Solubility

：

Molecular Weight

：

443.31

Storage and Stability

：

in stock

CAS No.

：

1393477-72-9

Purity

：

99.5%

Introduction

KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor. IC50 value: Target: CRM1 in vitro: As the clinical candidate analog of KPT-185, KPT-330 exhibits similar effects on the viability of T-ALL cells and elicits rapid apoptotic response. KPT-330 also reduces cell growth in MOLT-4, Jurkat, HBP-ALL, KOPTK-1, SKW-3, and DND-41 cell lines, with IC50 values of 34-203 nM [1]. in vivo: KPT-330 dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–11) in vivo, with little toxicity to normal haematopoietic cells [1]. In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330 directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and NFATc1, with minimal impact on osteoblasts and BMSCs [2].

Selinexor 1393477-72-9

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