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Uprosertib 1047634-65-0

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Synonyms ：
Appearance ：
white powder
Chemical Formula ：
C18H16Cl2F2N4O2
Solubility ：
Molecular Weight ：
429.25
Storage and Stability ：
in stock
CAS No. ：
1047634-65-0
Purity ：
99.5%
Introduction
GSK2141795 is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1). IC50 value: 180/328/38 nM (Akt1/2/3) Target: pan-Akt inhibitor KD values of 16 nM for Akt1, 49 nM for Akt2, and 5 nM for Akt3 (for GSK2141795), which are in line with literature data from biochemical assays that report potencies of 2 nM for Akt1, 2-13 nM for Akt2, and 3-9 nM Akt3 for GSK690693.

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