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ASP3026 1097917-15-1

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Synonyms ：
Appearance ：
white powder
Chemical Formula ：
C29H40N8O3S
Solubility ：
Molecular Weight ：
580.74
Storage and Stability ：
in stock
CAS No. ：
1097917-15-1
Purity ：
99.5%
Introduction
ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. IC50 value: 3.5 nM Target: ALK in vitro: ASP3026 shows more selective ALK inhibition in a Tyr-kinase panel than PF02341066. ASP3026 inhibits the growth of NCI-H2228, a human NSCLC tumor cell line endogenously expressing EML4-ALK variant 3, with an IC50 value of 64.8 nM . in vivo: ASP3026, administered to mice bearing subcutaneous NCI-H2228 tumor xenografts as twice daily oral dosing for 14 days, induces dose dependent anti-tumor effects starting at 1 mg/kg with strong regression at 10, 30 and 100 mg/kg.

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